Opioid |
Potency relative to oral morphine |
Notes |
Morphine PO |
1 |
|
Morphine SC / IV |
2 |
|
Diamorphine SC / IV |
3 |
|
Fentanyl transdermal, OFTC, SC or IV |
150 |
Absorption from mouth is transmucosal not enteral. Rapidly cleared. |
Codeine PO |
0.1 |
Conversion to morphine inconsistent no longer recommended in PPM. |
Tramadol PO |
0.2 |
Non-opioid analgesic effects may make tramadol more potent in practice |
Buprenorphine transdermal |
60 |
|
NB There is variability in both published evidence and in individual patients. Data is derived mainly from adults with cancer.