According to the bioavailability of the drug, medical condition and individual preference, the route of administration should be considered for each drug prescribed. These include:
Port-a-cath (an implantable port device positioned under the skin inserted into the subclavian vein)
Hickman Line (tunneled beneath the skin to a large vein)
Subcutaneous
Transdermal
Rectal
Epidural
Continuous Subcutaneous Infusions (CSCI) using a syringe driver are commonly used towards the end of life. Children can often be well managed using the NG/NJ/buccal and transdermal routes. Avoid repeated subcutaneous or intramuscular injections.
Unable to tolerate common routes of paediatric drug administration such as NG/NJ, buccal or transdermal
Difficultly swallowing
Persistent Vomiting
Bowel Obstruction
Not fully conscious
Unsatisfactory Response to Oral medications
Advantages of using this delivery system
continuous blood levels of medication
maintenance of mobility and independence
the ability to deliver complex drug combinations safely in the community
Improved certainty that the medication is reaching its target
Disadvantages of using a syringe driver
removes locus of care away from parents to “professionals”
another piece of medical equipment to distract from the child
costly in terms of daily nurse contact
technically challenging in neonate / malnourished child
Certain common combinations of drugs can be mixed together and given in the same syringe driver. Some drugs such as dexamethasone and other drugs in high concentrations will require the use of a separate syringe driver.
As a general rule it is advisable not to mix more than 3 drugs in any one driver though up to 5 have been used in particular circumstances. Check compatibility first.(see www.pallcare.info)